Extending query processing with big data pipelines of multi-omics data for better understanding of complex phenotypes

Scientific Context of the Project

Graph databases (GDB) have recently been arisen to overcome the limits of traditional databases for storing and managing data with graph-like structures. Graph-like structures are frequently used to represent the complex and arbitrary relations among attributes of real world data, such as atoms (nodes) and bonds (edges) in chemical structures, proteins (nodes) and protein interactions (edges) in biological networks.  Most of the techniques, applied to optimize queries in graph databases, have been used in traditional databases, distributed systems or they are inspired from graph theory. However, their reuse in graph databases should take care of the main characteristics of graph databases, such as size of data, dynamic structure, highly interconnected data, and ability to efficiently access data relationships. Characteristics of nucleic acid based data and querying this data for targeting various nucleic acid based treatments can benefit the technological support provided by specifically designed big data query processing pipelines. This research should investigate big data query processing methods for multi-omics data for better understanding of the genetic factors underlying complex phenotypes.

Innovative Aspects of the Project

Despite enormous time and money costs to generate them, the biological multi-omics data is rather heterogeneous in nature and very big in size that prevents effective utilization by scientists in the life sciences domains. The project will develop novel integration and query processing methods to overcome these challenges.

Research Environment and Infrastructure

IZTECH Computer Engineering Department will provide candidate modern technological and research-oriented infrastructure. (https://dworld.iyte.edu.tr/)

Project Acronym

(MOD-QP) Multi-Omics Data Query Processing

Main Supervisor

Assoc. Prof. Belgin Ergenç Bostanoğlu (IZTECH)


Assoc. Prof. Efe Sezgin (IZTECH)

Assoc. Prof. Gökhan Karakülah (IBG)

Recruiting Institution

İzmir Institute of Technology, Graduate School, Urla/İzmir

PhD Awarding Institution

İzmir Institute of Technology, Graduate School

PhD Title

PhD in Computer Engineering

International Academic Secondment

Barcelona Supercomputing Center, Barcelona, Spain or Polytechnic University of Catalonia, Barcelona, Spain

Intersectoral Mobility

Solaris Genomic Health (TR) and Istanbul Health Industry Cluster (ISEK)