Scientific Context of the Project

Mechanical signals are essential determinants of cell function and fate. Cessation or absence of mechanical loads such as a sedentary lifestyle, bedrest, stroke or spaceflight leads to a deterioration of tissue health in many organs.

For this study, we are interested in bone marrow mimicking 3D cultures and their response to microgravity. On earth microgravity will be facilitated by magnetic manipulation of cells, using diamagnetic levitation systems. Molecular and cellular adaptations to magnetic levitation will be documented and compared to in vivo studies as well as recorded spaceflight data.

Innovative Aspects of the Project

Ground-based microgravity assessment tools based on magnetic levitation.

Research Environment and Infrastructure

PhD candidates will be expected to work in an interdisciplinary environment with access to cell/tissue culture; cellular imaging and molecular biology tools as well as magnetic levitation-based culture technologies.

Preferred Academic Background

Biomedical Engineering, Bioengineering, Molecular Biology and Genetics

Required GRE Score

GRE Quantitative 157.00